To my mind something here does not add up, re. this new hypothesis that depression is a physical rather than mental illness.
So, most people who have depression are no strangers to anti-inflammatory drugs, in particular NSAIDs (Nonsteroidal anti-inflammatory drugs).
Yes, it is true that brain inflammation can be different to inflammation in other parts of the body. But it is believed that NSAIDs work on brain inflammations at least some of the time.
So, that is my concern. Given the huge population of people with BOTH depression and pain at least some percentage of these should have noticed an easing of their depression due to the NSAIDs they were taking. But, this has not been reported.
Hence my skepticism. Yes, it is possible that stronger, more specialized drugs are needed to fully combat depression-related brain inflammation. However, that NSAIDs have apparently not even scratched the surface bothers me.
What do YOU think?